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Last Update 2001.12.05

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(OKAUCHI, Tatsuo)










 エーザイ株式会社筑波研究所 探索第五研究部合成研究員


 九州工業大学工学部 助手


 九州工業大学工学部 講師


 九州工業大学工学部 助教授



日本化学会、有機合成化学協会、American Chemical Society







35. Okauchi,T.; Teshima, T.; Hayashi, K.; Suetsugu, N.; Minami, T., Regioselective Proton Abstraction and 1,3-Migration of a Phosphorus Group in 1,3-Dienes by Iron Coordination: A New Method for the Synthesis of alpha-Phosphono-alpha,beta-unsaturated Ketones, J. Am. Chem. Soc., 123(48), 12117-12118 (2001).

34. Ichikawa, J.; Fujiwara, M.; Miyazaki, S.; Ikemoto, M.; Okauchi, T.; Minami, T., Regioselective Nucleophilic Additions to Cross-Conjugated Dienone System Bearing beta-Fluorine: A Versatile Approach to Highly Substituted 2-Cyclopentenones, Org. Lett., 3(15), 2345-2348 (2001).

33. Wada, Y.; Ichikawa, J.; Katsume, T.; Nohiro, T.; Okauchi, T.; Minami, T., Intramolecular Cyclizations of o-Substituted beta,beta-Difluorostyrenes: Synthesis of 3-Fluorinated Isochromenes and Isothiochromenes, Bull. Chem. Soc. Jpn., 74(5), 971-977 (2001).

32. Okauchi, T.; Tanaka, T.; Minami T., Lewis Acid-Promoted Deoxygenative Di[beta,beta-bis(ethylthio)]vinylation of Aldehydes with Trimethylsilylketene Bis(ethylthio)acetal, J. Org. Chem., 66(11), 3924-3929, (2001).

31. Minami, T.; Okauchi, T.; Kouno, R., alpha-Phosphonovinyl Carbanions in Organic Synthesis, Synthesis, 2001(3), 349-357.

1. Y. Hashimoto, H. Sugumi, T. Okauchi, and T. Mukaiyama, The Trityl Cation Mediated Michael Reaction of Ethylthioketene Dithioacetals with Silyl Enol Ethers, Chem. Lett., 1987(9), 1691-1694.

2. Y. Hashimoto, H. Sugumi, T. Okauchi, and T. Mukaiyama, The Trityl Cation Catalyzed Michael Type Reaction of Stannylated Nucleophiles with Ethylthioketene Dithioacetals, Chem. Lett., 1987(9), 1695-1698.

3. Y. Ichikawa, H. Kubota, K. Fujita, T. Okauchi, and K. Narasaka, Stereoselective b-C- and b-S-Glycosylation of 2-Deoxyribofuranose Derivatives Controlled by the 3-Hydroxy Protecrive Group, Bull. Chem. Soc. Jpn., 62(3), 845-852 (1989).

4. T. Okauchi, H. Kubota, and K. Narasaka, Stereoselective Synthesis of b-2-Deoxyribonucleosides from 1-O-Acetyl-3-O-[2-(methylsulfinyl)ethyl]-2-deoxyribose, Chem. Lett., 1989(5), 801-804.

5. K. Narasaka, N. Miyoshi, K. Iwakura, and T. Okauchi, The Addition Reaction of b-Keto Carboxylic Acids to Olefinic Compounds by the Use of Mn(III) Tris(2-pyridinecarboxylate) as an Oxidant, Chem. Lett., 1989(12), 2169-2172.

6. K. Narasaka, K. Iwakura, and T. Okauchi, Addition Reactions of Cation Radicals of Nitroalkanes to Olefinic Compounds by the Use of Manganese(III) 2-Pyridinecarboxylate, Chem. Lett., 1991(3), 423-426.

7. K. Narasaka and T. Okauchi, Generation of Cation Radicals from Allylic Sulfides and Their Reactions with Silyl Enol Ethers by the Use of Cerium(IV) Ammonium Nitrate, Chem. Lett., 1991(3), 515-518.

8. K. Narasaka, N. Arai, and T. Okauchi, Generation of Cation Radicals from 2-Tributylstannyl-1,3-dithianes and Their Reaction with Olefins, Chem. Lett., 1992(7), 1229-1232.

9. K. Narasaka, T. Okauchi, K. Tanaka, and M. Murakami, Generation of Cation Radicals from Enamines and Their Reactions with Olefins, Chem. Lett., 1992(10), 2099-2102.

10. K. Narasaka, N. Arai, and T. Okauchi, Oxydative Generation of Thioalkyl Cation from 2-Tributylstannyl-1,3-ditianes and 1-(Tributylstannnyl)alkyl Sulfides and Their Reactions with Olefinic Nucleophiles, Bull. Chem. Soc. Jpn., 66(10), 2995-3003 (1993).

11. Y. Kotake, T. Okauchi, A. Iijima, K. Yoshimatsu, and H. Nomura, Novel 6-5 Fused Ring Heterocycle Antifolates with Potent Antitumor Activity: Bridge Modifications and Heterocyclic Benzoyl Isosters of 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Antifolate, Chem. Pharm. Bull., 43(5), 829-841 (1995).

12. T. Minami, Y. Okada, T. Otaguro, S. Tawaraya, T. Furuichi, and T. Okauchi, Development of Chiral Phosphine Ligands Bearing a Carboxyl Group and Their Application to Catalytic Asymmetric Reaction, Tetrahedron: Asymmetry, 6(10), 2469-2474 (1995).

13. J. Ichikawa, M. Fujiwara, H. Nawata, T. Okauchi, and T. Minami, Novel 2,2-Difluorovinylzirconocene: A Facile Synthesis of Monosubstituted gem-Difluoroolefins via Its Cross-Coupling Reaction, Tetrahedron Lett., 37(48), 8799-8802 (1996).

14. T. Minami, T. Okauchi, H. Matsuki, M. Nakamura, J. Ichikawa, and M. Ishida, Synthesis and Synthetic Application of Phosphonoketene Dithioacetals. New Synthesis of Dithioallenes and (alpha-Dithiocarboxyvinyl)phosphonates, J. Org. Chem., 61(23), 8132-8140 (1996).

15. J. Ichikawa, Y. Wada, T. Okauchi, and T. Minami, 5-endo-Trigonal cyclization of o-substituted gem-difluorostyrenes: Syntheses of 2-fluorinated indoles, benzo[b]furans, and benzo[b]thiophenes., Chem. Commun., 1997(16), 1537-1538.

16. T. Okauchi, T. Fukamachi, F. Nakamura, J. Ichikawa, and T. Minami, 2-Phosphono-1,1,4,4-tetrathio-1,3-butadienes. Synthesis and Synthetic Application to Highly Functionalized Dienes and Heterocycles, Bull. Soc. Chim. Belg., 106(9-10), 525-532 (1997).

17. T. Okauchi, T. Kakiuchi, N. Kitamura, T. Utsunomiya, J. Ichikawa, and T. Minami, Lewis Acid-Catalyzed Intramolecular [2+2] Cycloaddition of alpha -Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids, J. Org. Chem., 62(24), 8419-8424 (1997).

18. R. Kouno, T. Okauchi, M. Nakamura, J. Ichikawa, and T. Minami, Synthesis and Synthetic Utilization of alpha -Functionalized Vinylphosphonates Bearing beta-Oxy or beta-Thio Substitutents, J. Org. Chem., 63(18), 6239-6246 (1998).

19. J. Ichikawa, M. Fujiwara, T. Okauchi, and T. Minami, Fluorine-Directed Nazarov Cyclizations 2: Regioselective Synthesis of 5-Trifluoromethyl-2-cyclopentenones, Synlett, 1998(8), 927-929.

20. T. Okauchi, T. Yano, T. Fukamachi, J. Ichikawa, and T. Minami, Phosphonovinyl Nonaflate: Their Synthesis and Cross-Coupling Reactions, Tetrahedron Lett., 40(29), 5337-5340 (1999).

21. J. Ichikawa, H. Jyono, S. Yonemaru, T. Okauchi, and T. Minami, A Facile Synthesis of 1-H-2,2-Difluorovinylphosphorus Compounds from 2,2,2-Trifluoroethyl Trifluoromethanesulfonate and Substitutions of Their Vinylic Fluorines, J. Fluor. Chem., 97, 109-114 (1999).

22. T. Owa, H. Yoshino, T. Okauchi, K. Yoshimatsu, Y. Ozawa, N. H. Sugi, T. Nagasu, N. Koyanagi, and K. Kito, Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle, J. Med. Chem., 42, 3789-3799 (1999)

23. M. Fujiwara, J. Ichikawa, T. Okauchi, and T. Minami, Vinylic C-F Bond Activation: Generation and Cross-Coupling Reactions of 1-Fluorovinylzirconocene, Tetrahedron Lett., 40(40), 7261-7265 (1999).

24. T. Minami, R. Kouno, T. Okauchi, M. Nakamura, and J. Ichikawa, Synthetic Utilization of alpha-Phosphonovinyl Anions, Phosphorus, Sulfur and Silicon, 144-146, 689-692 (1999).

25. T. Okauchi, H. Nagamori, R. Kouno, J. Ichikawa, and T. Minami, Synthesis of 5-Diphenylphosphinoly-2,3-dihydropyran-4-ones, Heterocycles, 53(3), 1393-1398 (2000).

26. T. Okauchi,M. Itonaga,T. Minami, T. Owa, K. Kitoh, and H. Yoshino, General Method for Acylation of Indoles at the 3-Position with Acyl Chlorides in the Presence of Dialkylaluminum Chloride, Organic Lett., 2(10), 1485-1487 (2000).

27. T. Okauchi, K. Fujita, T. Ohtaguro, S. Ohshima, and T. Minami, Asymmetric Allylic Alkylation of Cycloalkenediol Diacetates Using a Chiral Phosphine Ligand Bearing a Carbonyl Group, Tetrahedron: Asymmetry, 11(6), 1397-1403 (2000).

28. T. Owa, T. Okauchi, K. Yoshimatsu, N. H. Sugi, Y. Ozawa, T. Nagasu, N. Koyanagi, T. Okabe, K. Kito, and Y. Yoshino, A Focused Compound Library of Novel N-(7-Indolyl)benzenesulfonamides for the Discovery of Potent Cell Cycle Inhibitors, Bioorg. Med. Chem. Lett., 10(11), 1223-1226 (2000).

29. R. Kouno, T. Tsubota, T. Okauchi, and T. Minami, Synthesis and Synthetic Application of alpha-Formylvinylphosphonates. Facile Synthesis of Phosphono-Substituted Heterocyclic Compounds, J. Org. Chem., 65(14), 4326-4332 (2000).

30. Ichikawa, J.; Fujiwara, M.; Wada, Y.; Okauchi, T.; T. Minami, T., The Nucleophilic 5-endo-trig Cyclization of gem-Difluoroolefins with Homoallylic functional group: syntheses of ring-fluorinated dihydroheteroaromatics, Chem. Commun., 2000(19), 1887-1888.

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