-Sorry, only in Japanese. I wish somebody would translate my home page free.

Last Update 2001.12.05

You are the th visitor

 


 

岡内辰夫

(OKAUCHI, Tatsuo)

物質工学科物質合成化学大講座

分子設計研究室、助教授

 

出身校又は最終学歴

東京大学大学院理学系研究科博士課程修了:博士(理学)(東京大学)

略歴

1964年11月19日(木)

 愛媛県松山市にて、誕生したらしい。

1992年4月〜1995年3月

 エーザイ株式会社筑波研究所 探索第五研究部合成研究員

1995年4月〜1999年8月

 九州工業大学工学部 助手

1999年9月〜

 九州工業大学工学部 講師

2002年6月〜

 九州工業大学工学部 助教授

現在に至る

所属学会等

日本化学会、有機合成化学協会、American Chemical Society

研究テーマ

金属−オレフィン錯体を利用した有機合成反応の開発

1電子移動反応を利用した炭素骨格形成反応の開拓

リン原子の特性を利用する新規有機合成反応の開発

一緒に働いた仲間

発表論文リスト

35. Okauchi,T.; Teshima, T.; Hayashi, K.; Suetsugu, N.; Minami, T., Regioselective Proton Abstraction and 1,3-Migration of a Phosphorus Group in 1,3-Dienes by Iron Coordination: A New Method for the Synthesis of alpha-Phosphono-alpha,beta-unsaturated Ketones, J. Am. Chem. Soc., 123(48), 12117-12118 (2001).

34. Ichikawa, J.; Fujiwara, M.; Miyazaki, S.; Ikemoto, M.; Okauchi, T.; Minami, T., Regioselective Nucleophilic Additions to Cross-Conjugated Dienone System Bearing beta-Fluorine: A Versatile Approach to Highly Substituted 2-Cyclopentenones, Org. Lett., 3(15), 2345-2348 (2001).

33. Wada, Y.; Ichikawa, J.; Katsume, T.; Nohiro, T.; Okauchi, T.; Minami, T., Intramolecular Cyclizations of o-Substituted beta,beta-Difluorostyrenes: Synthesis of 3-Fluorinated Isochromenes and Isothiochromenes, Bull. Chem. Soc. Jpn., 74(5), 971-977 (2001).

32. Okauchi, T.; Tanaka, T.; Minami T., Lewis Acid-Promoted Deoxygenative Di[beta,beta-bis(ethylthio)]vinylation of Aldehydes with Trimethylsilylketene Bis(ethylthio)acetal, J. Org. Chem., 66(11), 3924-3929, (2001).

31. Minami, T.; Okauchi, T.; Kouno, R., alpha-Phosphonovinyl Carbanions in Organic Synthesis, Synthesis, 2001(3), 349-357.

1. Y. Hashimoto, H. Sugumi, T. Okauchi, and T. Mukaiyama, The Trityl Cation Mediated Michael Reaction of Ethylthioketene Dithioacetals with Silyl Enol Ethers, Chem. Lett., 1987(9), 1691-1694.

2. Y. Hashimoto, H. Sugumi, T. Okauchi, and T. Mukaiyama, The Trityl Cation Catalyzed Michael Type Reaction of Stannylated Nucleophiles with Ethylthioketene Dithioacetals, Chem. Lett., 1987(9), 1695-1698.

3. Y. Ichikawa, H. Kubota, K. Fujita, T. Okauchi, and K. Narasaka, Stereoselective b-C- and b-S-Glycosylation of 2-Deoxyribofuranose Derivatives Controlled by the 3-Hydroxy Protecrive Group, Bull. Chem. Soc. Jpn., 62(3), 845-852 (1989).

4. T. Okauchi, H. Kubota, and K. Narasaka, Stereoselective Synthesis of b-2-Deoxyribonucleosides from 1-O-Acetyl-3-O-[2-(methylsulfinyl)ethyl]-2-deoxyribose, Chem. Lett., 1989(5), 801-804.

5. K. Narasaka, N. Miyoshi, K. Iwakura, and T. Okauchi, The Addition Reaction of b-Keto Carboxylic Acids to Olefinic Compounds by the Use of Mn(III) Tris(2-pyridinecarboxylate) as an Oxidant, Chem. Lett., 1989(12), 2169-2172.

6. K. Narasaka, K. Iwakura, and T. Okauchi, Addition Reactions of Cation Radicals of Nitroalkanes to Olefinic Compounds by the Use of Manganese(III) 2-Pyridinecarboxylate, Chem. Lett., 1991(3), 423-426.

7. K. Narasaka and T. Okauchi, Generation of Cation Radicals from Allylic Sulfides and Their Reactions with Silyl Enol Ethers by the Use of Cerium(IV) Ammonium Nitrate, Chem. Lett., 1991(3), 515-518.

8. K. Narasaka, N. Arai, and T. Okauchi, Generation of Cation Radicals from 2-Tributylstannyl-1,3-dithianes and Their Reaction with Olefins, Chem. Lett., 1992(7), 1229-1232.

9. K. Narasaka, T. Okauchi, K. Tanaka, and M. Murakami, Generation of Cation Radicals from Enamines and Their Reactions with Olefins, Chem. Lett., 1992(10), 2099-2102.

10. K. Narasaka, N. Arai, and T. Okauchi, Oxydative Generation of Thioalkyl Cation from 2-Tributylstannyl-1,3-ditianes and 1-(Tributylstannnyl)alkyl Sulfides and Their Reactions with Olefinic Nucleophiles, Bull. Chem. Soc. Jpn., 66(10), 2995-3003 (1993).

11. Y. Kotake, T. Okauchi, A. Iijima, K. Yoshimatsu, and H. Nomura, Novel 6-5 Fused Ring Heterocycle Antifolates with Potent Antitumor Activity: Bridge Modifications and Heterocyclic Benzoyl Isosters of 2,4-Diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine Antifolate, Chem. Pharm. Bull., 43(5), 829-841 (1995).

12. T. Minami, Y. Okada, T. Otaguro, S. Tawaraya, T. Furuichi, and T. Okauchi, Development of Chiral Phosphine Ligands Bearing a Carboxyl Group and Their Application to Catalytic Asymmetric Reaction, Tetrahedron: Asymmetry, 6(10), 2469-2474 (1995).

13. J. Ichikawa, M. Fujiwara, H. Nawata, T. Okauchi, and T. Minami, Novel 2,2-Difluorovinylzirconocene: A Facile Synthesis of Monosubstituted gem-Difluoroolefins via Its Cross-Coupling Reaction, Tetrahedron Lett., 37(48), 8799-8802 (1996).

14. T. Minami, T. Okauchi, H. Matsuki, M. Nakamura, J. Ichikawa, and M. Ishida, Synthesis and Synthetic Application of Phosphonoketene Dithioacetals. New Synthesis of Dithioallenes and (alpha-Dithiocarboxyvinyl)phosphonates, J. Org. Chem., 61(23), 8132-8140 (1996).

15. J. Ichikawa, Y. Wada, T. Okauchi, and T. Minami, 5-endo-Trigonal cyclization of o-substituted gem-difluorostyrenes: Syntheses of 2-fluorinated indoles, benzo[b]furans, and benzo[b]thiophenes., Chem. Commun., 1997(16), 1537-1538.

16. T. Okauchi, T. Fukamachi, F. Nakamura, J. Ichikawa, and T. Minami, 2-Phosphono-1,1,4,4-tetrathio-1,3-butadienes. Synthesis and Synthetic Application to Highly Functionalized Dienes and Heterocycles, Bull. Soc. Chim. Belg., 106(9-10), 525-532 (1997).

17. T. Okauchi, T. Kakiuchi, N. Kitamura, T. Utsunomiya, J. Ichikawa, and T. Minami, Lewis Acid-Catalyzed Intramolecular [2+2] Cycloaddition of alpha -Ester-Substituted Conjugated Dienyl- and Trienylphosphonates. New Synthesis of Functionalized Cyclic Terpenoids, J. Org. Chem., 62(24), 8419-8424 (1997).

18. R. Kouno, T. Okauchi, M. Nakamura, J. Ichikawa, and T. Minami, Synthesis and Synthetic Utilization of alpha -Functionalized Vinylphosphonates Bearing beta-Oxy or beta-Thio Substitutents, J. Org. Chem., 63(18), 6239-6246 (1998).

19. J. Ichikawa, M. Fujiwara, T. Okauchi, and T. Minami, Fluorine-Directed Nazarov Cyclizations 2: Regioselective Synthesis of 5-Trifluoromethyl-2-cyclopentenones, Synlett, 1998(8), 927-929.

20. T. Okauchi, T. Yano, T. Fukamachi, J. Ichikawa, and T. Minami, Phosphonovinyl Nonaflate: Their Synthesis and Cross-Coupling Reactions, Tetrahedron Lett., 40(29), 5337-5340 (1999).

21. J. Ichikawa, H. Jyono, S. Yonemaru, T. Okauchi, and T. Minami, A Facile Synthesis of 1-H-2,2-Difluorovinylphosphorus Compounds from 2,2,2-Trifluoroethyl Trifluoromethanesulfonate and Substitutions of Their Vinylic Fluorines, J. Fluor. Chem., 97, 109-114 (1999).

22. T. Owa, H. Yoshino, T. Okauchi, K. Yoshimatsu, Y. Ozawa, N. H. Sugi, T. Nagasu, N. Koyanagi, and K. Kito, Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle, J. Med. Chem., 42, 3789-3799 (1999)

23. M. Fujiwara, J. Ichikawa, T. Okauchi, and T. Minami, Vinylic C-F Bond Activation: Generation and Cross-Coupling Reactions of 1-Fluorovinylzirconocene, Tetrahedron Lett., 40(40), 7261-7265 (1999).

24. T. Minami, R. Kouno, T. Okauchi, M. Nakamura, and J. Ichikawa, Synthetic Utilization of alpha-Phosphonovinyl Anions, Phosphorus, Sulfur and Silicon, 144-146, 689-692 (1999).

25. T. Okauchi, H. Nagamori, R. Kouno, J. Ichikawa, and T. Minami, Synthesis of 5-Diphenylphosphinoly-2,3-dihydropyran-4-ones, Heterocycles, 53(3), 1393-1398 (2000).

26. T. Okauchi,M. Itonaga,T. Minami, T. Owa, K. Kitoh, and H. Yoshino, General Method for Acylation of Indoles at the 3-Position with Acyl Chlorides in the Presence of Dialkylaluminum Chloride, Organic Lett., 2(10), 1485-1487 (2000).

27. T. Okauchi, K. Fujita, T. Ohtaguro, S. Ohshima, and T. Minami, Asymmetric Allylic Alkylation of Cycloalkenediol Diacetates Using a Chiral Phosphine Ligand Bearing a Carbonyl Group, Tetrahedron: Asymmetry, 11(6), 1397-1403 (2000).

28. T. Owa, T. Okauchi, K. Yoshimatsu, N. H. Sugi, Y. Ozawa, T. Nagasu, N. Koyanagi, T. Okabe, K. Kito, and Y. Yoshino, A Focused Compound Library of Novel N-(7-Indolyl)benzenesulfonamides for the Discovery of Potent Cell Cycle Inhibitors, Bioorg. Med. Chem. Lett., 10(11), 1223-1226 (2000).

29. R. Kouno, T. Tsubota, T. Okauchi, and T. Minami, Synthesis and Synthetic Application of alpha-Formylvinylphosphonates. Facile Synthesis of Phosphono-Substituted Heterocyclic Compounds, J. Org. Chem., 65(14), 4326-4332 (2000).

30. Ichikawa, J.; Fujiwara, M.; Wada, Y.; Okauchi, T.; T. Minami, T., The Nucleophilic 5-endo-trig Cyclization of gem-Difluoroolefins with Homoallylic functional group: syntheses of ring-fluorinated dihydroheteroaromatics, Chem. Commun., 2000(19), 1887-1888.



分子設計研ホームページ 応用化学ホームページ 九工大ホームページ